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KMID : 0811720070110030113
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Korean Journal of Physiology & Pharmacology
2007 Volume.11 No. 3 p.113 ~ p.119
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Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
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Kim Jae-Goo
Lee Jong-Doo
Kim Min-Soo
Lee Seo-Ul
Kim Gun-Tae
Kim Dong-Goo
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Abstract
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Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a 5-HT1A receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.
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KEYWORD
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Developmental disability, Lipopolysaccharide, 5-HT1A receptor, Animal model
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